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Neural tube defects.
In: Salem Press Encyclopedia of Health, 2022-01-31, S. 3
Online
Nachschlagewerk
Zugriff:
The neural tube develops out of the neural plate and differentiates into the brain and spinal cord. Neurulation is a complex process of organized gene expression in which the thickened epithelial cells that make up the neural plate change shape, migrate, and differentiate at precise intervals to form a hollow tube. During convergent extension (CE), cells narrow and lengthen and the borders fold, forming the neural groove, which becomes progressively deeper with cell division. The neural tube begins to form as the dorsal folds meet and fuse along the midline. Closure begins in the cervical region, extends along the rostral/caudal plane, and ends at the anterior and posterior neuropores around twenty-four and twenty-eight days after conception, respectively. At the cephalic (head) end of the neural tube, three cavities form and differentiate into the forebrain, midbrain, and hindbrain; midway, the walls (epithelium) develop into cells of the nervous system; and the caudal (tail) end becomes the spinal cord. NTDs can result when any of the steps in this process is disrupted.
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Neural tube defects.
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Autor/in / Beteiligte Person: | Sandford, Mary K., PhD ; Woldin, Barbara |
Zeitschrift: | Salem Press Encyclopedia of Health, 2022-01-31, S. 3 |
Veröffentlichung: | 2022 |
Medientyp: | Nachschlagewerk |
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