Early Clinical Experiences With the New Influenza A (H1N1/09) von Dr. med. Ralf Winzer, Nicolas Kanig, Sophie Schneitler, PD Dr. med. Stefan Reuter, Dr. med. Björn Jensen, Dr. med. Irmela Müller-Stöver, Dr. med. Jun Oh, Prof. Dr. med. Ortwin Adams, Prof. Dr. med. Ertan Mayatepek, Prof. Dr. med. Hartmut Hengel, Prof. Dr. med. Heiko Schneitler, Prof. Dr. med. Dieter Häussinger in Heft 47/2009
Winzer et al report early experiences with the new influenza A (H1N1/09) for the time period from April to September 2009. The authors emphasize that the disease course was mostly mild and rarely necessitated inpatient treatment. In most cases-including children-nothing worse than the typical flu symptoms were diagnosed.
We wish to share our own observations of an unexpected rate of neurological complications in 6 hospitalized children (age: 6 weeks to 8 years) infected with the influenza virus A(H1N1/09) in Berlin in November 2009. In addition to flu symptoms (and, in one case, initially gastrointestinal symptoms), the disease manifested, or over the initial 3 days presented, as impaired consciousness levels, somnolence, agitation (in some cases accompanied by hallucinations), and seizures (in 2 schoolchildren who were not of the age when febrile seizures usually occur). One patient had to be mechanically ventilated because of central breathing disorder with apneas/attacks of cyanosis and intermittent hyperventilation (pCO2
As is the case for seasonal influenza (
DOI: 10.3238/arztebl.2010.0229a
By Philipp Deindl, Otto-Heubner-Centrum für Kinderheilkunde/Jugendmedizin Charité (CVK) Augustenburger Platz 1 13353 Berlin and Verena Varnholt, Otto-Heubner-Centrum für Kinderheilkunde/Jugendmedizin Charité (CVK) Augustenburger Platz 1 13353 Berlin