Comparison of long-term efficacy and safety of risperidone and haloperidol in children and adolescents with autistic disorder: an open label maintenance study.
In: European Child & Adolescent Psychiatry, Jg. 17 (2008-06-01), Heft 4, S. 217-225
Online
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Zugriff:
Background: The aim of the study was to investigate safety, efficacy and tolerability of risperidone in comparison with haloperidol in the long-term treatment of autistic disorder. Methods: his was an open-label continuation study of the randomized, double-blind, controlled trial of risperidone and haloperidol study for 12 week in autistic children and adolescents. A total of 28 subjects between 8 and 18 ages with autistic disorder were enrolled to the open label phase of the study. Behavioral rating scales (Clinical Global Impression Scale [CGI-I], Ritvo-Freeman Real Life Rating Scale [RF-RLRS]), Aberrant Behavior Checklist [ABC], Turgay DSM-IV Pervasive Developmental Disorder Rating Scale [TPDDRS]) and safety assessment scales (Extrapyramidal Symptoms Rating Scale [ESRS], UKU-Side Effect Rating Scale) were performed at 12, 16, 20 and 24 weeks, following the 12 week double-blind phase. Risperidone and haloperidol treatments were applied with a once daily dosage regimen as 0.01-0.08 mg/kg/day. Results: Risperidone led to a significant greater reduction on CGI scale. There was significant improvement on RF-RLRS sensory motor and language subscale and ABC scores in risperidone group. Weight gain was observed more frequently in the haloperidol group at week 24. Conclusions: These results demonstrate that risperidone is more efficacious and well tolerated than haloperidol in the long-term maintenance treatment of autistic disorder. [ABSTRACT FROM AUTHOR]
Titel: |
Comparison of long-term efficacy and safety of risperidone and haloperidol in children and adolescents with autistic disorder: an open label maintenance study.
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Autor/in / Beteiligte Person: | Gencer, O ; Emiroglu, F ; Miral, S ; Baykara, B ; Baykara, A ; Dirik, E |
Link: | |
Zeitschrift: | European Child & Adolescent Psychiatry, Jg. 17 (2008-06-01), Heft 4, S. 217-225 |
Veröffentlichung: | 2008 |
Medientyp: | academicJournal |
ISSN: | 1018-8827 (print) |
DOI: | 10.1007/s00787-007-0656-6 |
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