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Relapse prevention by citalopram in SAD patients responding to 1 week of light therapy. A placebo-controlled study.
In: Acta Psychiatrica Scandinavica, Jg. 109 (2004-03-01), Heft 3, S. 230-234
Online
academicJournal
Zugriff:
Martiny K, Lunde M, Simonsen C, Clemmensen L, Poulsen DL, Solstad K, Bech P. Relapse prevention by citalopram in SAD patients responding to 1 week of light therapy. A placebo-controlled study. Acta Psychiatr Scand 2004: 109: 230–234. © Blackwell Munksgaard 2004. We have tested the relapse-preventive effect of citalopram when compared with placebo in 282 patients with Seasonal Affective Disorder (SAD) responding to 1 week of light therapy. The response rate to 1-week light therapy and relapse during the continuation phase of 15 weeks were assessed by use of the Hamilton Depression Rating Scale (HAM-D17), the six-item subscale (HAM-D6), the Melancholia Scale (MES), and the combined HAM-D/SIGH-SAD. The response rate to light therapy was 62.5% on the HAM-D17 and the HAM-D6, 56.1% on the HAM-D/SIGH-SAD, 52.8% on the MES. In the continuation phase, citalopram was found superior to placebo on all scales, but the difference was only of statistical significance on the HAM-D6 and the MES. Mean citalopram dose was 26.3 mg. Light therapy was found to have and early onset of action. On the HAM-D6 and the MES citalopram significantly reduced the relapse rate in the continuation phase. [ABSTRACT FROM AUTHOR]
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Relapse prevention by citalopram in SAD patients responding to 1 week of light therapy. A placebo-controlled study.
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Autor/in / Beteiligte Person: | Martiny, K. ; Lunde, M. ; Simonsen, C. ; Clemmensen, L. ; Poulsen, D. L. ; Solstad, K. ; Bech, P. |
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Zeitschrift: | Acta Psychiatrica Scandinavica, Jg. 109 (2004-03-01), Heft 3, S. 230-234 |
Veröffentlichung: | 2004 |
Medientyp: | academicJournal |
ISSN: | 0001-690X (print) |
DOI: | 10.1046/j.1600-0447.2003.00256.x |
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