Volltext verfügbar nach Anmeldung bzw. im Campus-Netz.
Changes of hippocampus proteomic profiles after blueberry extracts supplementation in APP/PS1 transgenic mice.
In: Nutritional Neuroscience, Jg. 23 (2020), Heft 1, S. 75-84
Online
academicJournal
Zugriff:
Objective: To examine protein changes in the hippocampus of APP/PS1 transgenic mice after blueberry extracts (BB) intervention. Methods: Eight APP/PS1 transgenic mice were randomly assigned to Alzheimer's disease (AD)+BB group (n=4) and AD+control group (n=4). After a 16-week treatment, 2-DE and MALDI-TOF-MS were used to compare the proteomic profiles of the hippocampus in the two groups and Western blot was used to confirm the important differentially expressed proteins. Results: Twelve proteins were differentially expressed between the two groups. Nine of them were identified. Cytochrome b-c1 complex subunit 6, beta-actin, dynamin 1, and heat shock cognate 71 were up-regulated in AD+BB group, while a-enolase, stress-induced-phosphoprotein 1, malate dehydrogenase (MDH), MDH 1, and T-complex protein 1 subunit beta were down-regulated, respectively. Importantly, some of the identified proteins (e.g. dynamin 1) are known to be involved in cognitive impairment. Western blot analysis of hippocampus dynamin 1 expression confirmed the proteomic findings. Conclusions: The consumption of BB modulates the expression of proteins that are linked to the improvements of cognitive dysfunction in hippocampus of APP/PS1 transgenic mice. [ABSTRACT FROM AUTHOR]
Titel: |
Changes of hippocampus proteomic profiles after blueberry extracts supplementation in APP/PS1 transgenic mice.
|
---|---|
Autor/in / Beteiligte Person: | Li, Hai-qiang ; Tan, Long ; Yang, Hong-peng ; Pang, Wei ; Xu, Tong ; Jiang, Yu-gang |
Link: | |
Zeitschrift: | Nutritional Neuroscience, Jg. 23 (2020), Heft 1, S. 75-84 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 1028-415X (print) |
DOI: | 10.1080/1028415X.2018.1471251 |
Schlagwort: |
|
Sonstiges: |
|