Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques.
In: Nature, Jg. 586 (2020-10-22), Heft 7830, S. 583-588
Online
academicJournal
Zugriff:
A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be required to end the coronavirus disease 2019 (COVID-19) pandemic1–8. For global deployment and pandemic control, a vaccine that requires only a single immunization would be optimal. Here we show the immunogenicity and protective efficacy of a single dose of adenovirus serotype 26 (Ad26) vector-based vaccines expressing the SARS-CoV-2 spike (S) protein in non-human primates. Fifty-two rhesus macaques (Macaca mulatta) were immunized with Ad26 vectors that encoded S variants or sham control, and then challenged with SARS-CoV-2 by the intranasal and intratracheal routes9,10. The optimal Ad26 vaccine induced robust neutralizing antibody responses and provided complete or near-complete protection in bronchoalveolar lavage and nasal swabs after SARS-CoV-2 challenge. Titres of vaccine-elicited neutralizing antibodies correlated with protective efficacy, suggesting an immune correlate of protection. These data demonstrate robust single-shot vaccine protection against SARS-CoV-2 in non-human primates. The optimal Ad26 vector-based vaccine for SARS-CoV-2, termed Ad26.COV2.S, is currently being evaluated in clinical trials. The protective efficacy of a single dose of adenovirus serotype 26 (Ad26) vector-based vaccine expressing the SARS-CoV-2 spike protein in non-human primates is demonstrated. [ABSTRACT FROM AUTHOR]
Titel: |
Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques.
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Autor/in / Beteiligte Person: | Mercado, Noe B. ; Zahn, Roland ; Wegmann, Frank ; Loos, Carolin ; Chandrashekar, Abishek ; Yu, Jingyou ; Liu, Jinyan ; Peter, Lauren ; McMahan, Katherine ; Tostanoski, Lisa H. ; He, Xuan ; Martinez, David R. ; Rutten, Lucy ; Bos, Rinke ; van Manen, Danielle ; Vellinga, Jort ; Custers, Jerome ; Langedijk, Johannes P. ; Kwaks, Ted ; Bakkers, Mark J. G. |
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Zeitschrift: | Nature, Jg. 586 (2020-10-22), Heft 7830, S. 583-588 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 0028-0836 (print) |
DOI: | 10.1038/s41586-020-2607-z |
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