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Relationship between cerebrospinal fluid/serum albumin quotient and phenotype in amyotrophic lateral sclerosis: a retrospective study on 328 patients.
In: Neurological Sciences, Jg. 44 (2023-05-01), Heft 5, S. 1679-1685
Online
academicJournal
Zugriff:
Background: We analysed the relationship between cerebrospinal fluid (CSF)/serum albumin quotient (Q-Alb) and phenotype in a large cohort of patients with amyotrophic lateral sclerosis (ALS). Methods: Three hundred twenty-eight single-centre consecutive patients with ALS were evaluated for Q-Alb, basic epidemiological and clinical data, motor phenotype, cognitive/behavioural impairment, clinical staging, clinical and neurophysiological indexes of upper (UMN) and lower motor neuron (LMN) dysfunction, and presence of ALS gene mutations. Results: Q-Alb did not correlate with age but was independently associated with sex, with male patients having higher levels than female ones; the site of onset was not independently associated with Q-Alb. Q-Alb was not associated with motor phenotype, cognitive/behavioural impairment, disease stage, progression rate, survival, or genetic mutations. Among measures of UMN and LMN dysfunction, Q-Alb only had a weak positive correlation with an electromyography-based index of active limb denervation. Conclusion: Previous work has documented increased Q-Alb in ALS compared to unaffected individuals. This, together with the absence of associations with nearly all ALS phenotypic features in our cohort, suggests dysfunction of the blood-CSF barrier as a shared, phenotype-independent element in ALS pathophysiology. However, correlation with the active denervation index could point to barrier dysfunction as a local driver of LMN degeneration. [ABSTRACT FROM AUTHOR]
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Relationship between cerebrospinal fluid/serum albumin quotient and phenotype in amyotrophic lateral sclerosis: a retrospective study on 328 patients.
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Autor/in / Beteiligte Person: | Verde, Federico ; Ferrari, Ivan ; Maranzano, Alessio ; Ciusani, Emilio ; Torre, Silvia ; Milone, Ilaria ; Colombo, Eleonora ; Doretti, Alberto ; Peverelli, Silvia ; Ratti, Antonia ; Maderna, Luca ; Poletti, Barbara ; Messina, Stefano ; Morelli, Claudia ; Silani, Vincenzo ; Ticozzi, Nicola |
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Zeitschrift: | Neurological Sciences, Jg. 44 (2023-05-01), Heft 5, S. 1679-1685 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1590-1874 (print) |
DOI: | 10.1007/s10072-023-06604-3 |
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