Gender Difference in Neuronal Recordings during Stereotactic Neurosurgery for Deep Brain Stimulation for Parkinson's Disease.
In: American Journal of Electroneurodiagnostic Technology, Jg. 47 (2007-12-01), Heft 4, S. 315-316
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Zugriff:
The human brain substantially differs between males and females. In Parkinson's disease (PD) there are gender-related differences in the disease incidence, in the motor performance, and in the incidence of dyskinesias. Deep brain stimulation (DBS) is an established therapy for advanced PD and offers a unique opportunity to record the electrical activity from the basal ganglia. In this study we sought possible gender-related differences in the electrical activity of the subthalamic area by studying neuronal action potentials (APs) and local field potentials (LDPs). APs were recorded during neurosurgical procedures for the implantation of electrodes in the subthalamic nucleus (STN) in the 31 sides of the brain in patients with idiopathic PD. LFPs were recorded soon after surgery through DBS electrodes in 24 patients (males = 12, females 12). AP analysis showed that males had larger spike area and amplitude (amplitude: 41.97 ± 32.57 vs 26.2 ± 19.7 µV, p < 0.001; area; 31.8 ± 26.4 vs 13.0 ± 10.6 µV/msec, p < 0.001), whereas females had higher mean total firing rate (66.7 ± 53.4 vs 82.8 ± 50.8 Hz, p < 0.05). LFP recordings at rest before levodopa medication showed significantly higher power in the alpha/low beta band (8 to 12 Hz, p < 0.01; 13 to 20 Hz, p = 0.03) in females than in males. After levodopa administration, the power in the high-gamma band (60 to 90 Hz) and of the 300 Hz rhythm was significantly higher in females than in males (high gamma: p = 0.007; 300 Hz: p = 0.002). Our results show significant gender-related differences in the electrical activity of the human STN area in PD. [ABSTRACT FROM AUTHOR]
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Gender Difference in Neuronal Recordings during Stereotactic Neurosurgery for Deep Brain Stimulation for Parkinson's Disease.
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Autor/in / Beteiligte Person: | Mrakic-Sposta, S. ; Marceglia, S. ; Vegargi, M. ; Cogiamanian, F. ; Dilena, R. ; Ferrucci, R. ; Leone, A. ; Mameli, F. ; Barbieri, S. ; Priori, A. |
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Zeitschrift: | American Journal of Electroneurodiagnostic Technology, Jg. 47 (2007-12-01), Heft 4, S. 315-316 |
Veröffentlichung: | 2007 |
Medientyp: | academicJournal |
ISSN: | 1086-508X (print) |
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