Cognitive enhancing effects in young and old rats of pBC[sub 264] , a selective CCK[sub B] receptor agonist.
In: Psychopharmacology, Jg. 143 (1999-05-15), Heft 2, S. 141-149
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Zugriff:
Abstract Rationale: The implication of CCK[sub B] receptors in cognitive processes is far from fully understood. Objective: The present study investigated the effect of propionyl-BC[sub 264], a selective agonist of CCK[sub B] receptors, in young and old rats. Methods: Cognitive functions were studied in a two-trial recognition memory task developed in our laboratory. Results: It was shown that propionyl-BC[sub 264] enhanced information processing in young as well as in old rats when injected (10 micro g/kg; IP) immediately after the acquisition phase and before the retrieval trial but not before the acquisition trial. This cognitive enhancing effect was blocked by prior administration of L 365,260, a selective CCK[sub B] receptor antagonist. Conclusions: In view of the fact that BC[sub 264] is devoid of anxiogenic effects, it could be of value in the treatment of cognitive impairments associated with both normal and pathological ageing. [ABSTRACT FROM AUTHOR]
Titel: |
Cognitive enhancing effects in young and old rats of pBC[sub 264] , a selective CCK[sub B] receptor agonist.
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Autor/in / Beteiligte Person: | Taghzouti, K. ; Léna, I. ; Dellu, F. ; Roques, B. P. ; Daugé, V. ; Simon, H. |
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Zeitschrift: | Psychopharmacology, Jg. 143 (1999-05-15), Heft 2, S. 141-149 |
Veröffentlichung: | 1999 |
Medientyp: | academicJournal |
ISSN: | 0033-3158 (print) |
DOI: | 10.1007/s002130050929 |
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