Reduced ventral striatal/ventral pallidal serotonin receptor binding potential in major depressive disorder.
In: Psychopharmacology, Jg. 213 (2011-02-01), Heft 2/3, S. 547-553
Online
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Zugriff:
Rationale: Although serotonin (5-HT) dysregulation is implicated in the pathophysiology of major depressive disorder (MDD), the role of specific receptor subtypes remains to be elucidated. Emerging preclinical research suggests an important role for the 5-HT receptor in behavioral regulation and depressive phenotypes. In particular, 5-HT heteroreceptors located within the striatum have been shown to play an essential role in antidepressant action. Objectives: The objective of this study was to determine 5-HT receptor binding potential ( BP) in the region of the ventral striatum/ventral pallidum (VS/VP) in individuals with MDD and healthy control participants. Methods: Ten participants with MDD (30.8 ± 9.5 years, five men/five women) in a current major depressive episode (MDE) and ten healthy control participants (30.7 ± 10.5 years, five men/five women) underwent positron emission tomography (PET) scanning with the selective 5-HT receptor radioligand [C]P943. Results: Within the VS/VP region of interest, [C]P943 BP was significantly reduced in the MDD group compared with the healthy control group (1.37 ± 0.13 and 1.68 ± 0.16, respectively; 18.7% between-group difference; p < 0.001). Conclusions: Consistent with preclinical and postmortem data, our findings suggest abnormally reduced function of VS/VP 5-HT receptors in humans with MDD. Abnormal 5-HT heteroreceptor function may contribute to dysfunctional reward signaling within the striatum, including the nucleus accumbens, via interaction with dopamine, γ-amino-butyric acid, or glutamate systems. Our findings suggest reduced 5-HT receptor signaling in the VS/VP in MDD and contribute to the therapeutic rationale for testing 5-HT agonists as a novel class of antidepressants. [ABSTRACT FROM AUTHOR]
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Reduced ventral striatal/ventral pallidal serotonin receptor binding potential in major depressive disorder.
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Autor/in / Beteiligte Person: | Murrough, James ; Henry, Shannan ; Hu, Jian ; Gallezot, Jean-Dominique ; Planeta-Wilson, Beata ; Neumaier, John ; Neumeister, Alexander |
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Zeitschrift: | Psychopharmacology, Jg. 213 (2011-02-01), Heft 2/3, S. 547-553 |
Veröffentlichung: | 2011 |
Medientyp: | academicJournal |
ISSN: | 0033-3158 (print) |
DOI: | 10.1007/s00213-010-1881-0 |
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