Self-reported symptoms in patients on antiepileptic drugs in monotherapy.
In: Acta Neurologica Scandinavica, Jg. 124 (2011-11-01), Heft 5, S. 355-358
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Zugriff:
Wieshmann UC, Tan GM, Baker G. Self-reported symptoms in patients on antiepileptic drugs in monotherapy. Acta Neurol Scand: 2011: 124: 355-358. © 2011 John Wiley & Sons A/S. Objective - To ascertain the frequency of self-reported symptoms in patients taking antiepileptic drugs (AED). Methods - We included patients on carbamazepine (CBZ) n = 36, valproate (VPA) n = 21, levetiracetam (LEV) n = 12, phenytoin (PHT) n = 11, lamotrigine (LTG) n = 20, patients not taking anticonvulsive drugs n = 19, and healthy control subjects (CTRL) n = 41 to complete the Liverpool Adverse Event Profile (LAEP). Results - The mean LAEP scores were CBZ/PHT/LEV/VPA/LTG/noAED/CTRL = 44.97/42.00/41.00/40.33/32.42/42.00/30.80. LEV scored overall in the same range as the older AED but had a different adverse effect profile with self-reported anger (33%) and shaky hands (42%) particularly frequent. Patients with depression or uncontrolled epilepsy had significantly higher LAEP scores than patients without depression or uncontrolled epilepsy. Conclusion - Our unblinded observational study of self-reported symptoms suggested LTG was overall the drug with the least self-reported symptoms. Larger studies are needed to determine whether this was a truly significant difference. LEV had a different side effect profile to older AED. Confounding factors were depression and uncontrolled epilepsy. This observation should be further tested with randomized studies. [ABSTRACT FROM AUTHOR]
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Self-reported symptoms in patients on antiepileptic drugs in monotherapy.
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Autor/in / Beteiligte Person: | Wieshmann, U. C. ; Tan, G. M. ; Baker, G. |
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Zeitschrift: | Acta Neurologica Scandinavica, Jg. 124 (2011-11-01), Heft 5, S. 355-358 |
Veröffentlichung: | 2011 |
Medientyp: | academicJournal |
ISSN: | 0001-6314 (print) |
DOI: | 10.1111/j.1600-0404.2011.01488.x |
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